Primary hyperoxaluria (PH) is a rare autosomal genetic form of Hyperoxaluria, a condition that leads to the excessive urinary excretion of oxalate. Till now, three distinct hereditary enzymatic deficiencies have been identified as a cause of PH, namely, PH type 1 (PH1), type 2 (PH2), and type 3 (PH3), with PH1 as the most common form of PH. Each of the three types is caused by a genetic aberration in a gene that regulates the production of a different hepatic enzyme, a mutation that results in the overproduction of oxalate by the liver.
Worldwide Primary hyperoxaluria prevalence is estimated to range from 1 to 3 per million population. Primary hyperoxaluria c...
