Oncology

Bruton's Tyrosine Kinase (BTK) is a cytoplasmic member from the Tec (tyrosine kinase expressed in hepatocellular carcinoma) group of kinases which is engaged with controlling the B cell expansion and is essential in B-lymphocyte advancement, separation, and signaling. Bruton's tyrosine kinase; also known as tyrosine-protein kinase enzyme, is encoded by the BTK gene in human and is the only member of the Tec family that causes disease in humans. XLA is an essential immunodeficiency resulting because of mutations in BTK. BTK plays an essential role in B-cell receptor signaling and is also involved in CD40 ligation, Toll-like receptor activation, and Fc-receptor signaling...