Improving cancer immunotherapy by recovering a warning system
Cancer cells, most of the time, develop tactics to elude the immune system. A research team that is led by scientists at Memorial Sloan Kettering Cancer Center has recognized one such mechanism, and it believes aiming it with drugs could potentially enhance responses to immuno-oncology treatments.
A protein called ENPP1, which coats cancer cells, impedes warning signals of tumor formation before they can reach immune cells, the researchers elucidated in a study published in the journal Cancer Discovery.
In mouse models of breast and colorectal cancers, the team showed detaching ENPP1 made the tumor...
