Oncolytic viruses (OVs) represent a new category of cancer treatments that provide several advantages: they selectively replicate within tumor cells, can deliver various eukaryotic transgene payloads, induce immunogenic cell death, enhance antitumor immunity, and generally have a safe profile that doesn't significantly overlap with other cancer therapies.
Oncolytic viruses emerge as a way of bypassing the immune evasion mechanisms of the tumor, aiming to improve the clinical condition of patients through the stimulation of the host immune system or direct lysis of abnormal cells.
Oncolytic viruses are either RNA or DNA viruses. RNA viruses such as reoviruses, pa...
