Functional β-cell mass
Sep 26, 2018
Can GABA turn pancreatic α-cells into β-cells?
Functional β-cell mass loss leads to the pathogenesis of type 1 diabetes mellitus (T1DM) and also adds to type 2 diabetes mellitus (T2DM). Genetically induced downregulation of Arx, a key transcription factor for glucagon-producing α-cell specification and phenotype, in α-cells converts them into insulin-producing β...
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