T-cell receptors

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hpk1-inhibitors-assessment
HPK1 Inhibitors: A Promising Frontier in Immuno-Oncology Therapeutics

Hematopoietic progenitor kinase (HPK1) belongs to the family of Ste20 serine/threonine kinases known as mitogen-activated protein kinase kinase kinase kinase (MAP4K). It is primarily expressed in hematopoietic cells and functions as a negative regulator of T-cell receptor (TCR) and B-cell signaling, serving as an i...

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