Progressive multifocal leukoencephalopathy is a severe, progressive, and lethal demyelinating disease that presents in immunocompromised states. It is a rare indication, with just over 1.5K PML diagnosed incident cases in the United States, per DelveInsight analysis. It occurs in the setting of predisposing immunosuppressive conditions like HIV, hematological malignancies, and treatment with chemotherapy and autoimmune medications. According to our estimates, in the United States, >900 patients develop PML due to HIV infection, followed by hematological malignancies (around 300 cases) and chemotherapy medications (>200 cases). Autoimmune medications result in ~1...
