In the contemporary world, major depressive disorder (MDD) is one of the diseases responsible for the greatest healthcare burden. In the United States, more than 24 million people suffer from major depressive disorder each year, while in Europe, about 20 million are diagnosed with the major depressive disorder each year. These numbers might not be an accurate reflection owning to continuous ignorance about mental health issues as well as a social stigma associated with mental health conditions.
A plethora of pharmacological drugs from different classes acting by more than half a dozen mechanisms are available for major depressive disorder treatment. However, a sign...