Multiple system atrophy (MSA) is a progressive neurodegenerative disorder characterized by a constellation of symptoms impacting both the autonomic nervous system and motor function. According to the National Organization for Rare Disorders (NORD), MSA affects between 15,000 and 50,000 individuals in the United States, affecting men and women across all racial groups. The etiology of MSA remains unknown, with the vast majority of cases occurring sporadically and without a clear cause. The peak onset typically occurs between the ages of 55 and 60, although onset can range from as early as 30 to beyond 90 years of age. NORD estimates the incidence of MSA in the US gener...
