Treatment-resistant Depression (TRD) typically refers to inadequate response to at least two antidepressant medications used for a sufficient length of time at an adequate dose with an adequate affirmation of treatment adherence. Treatment-resistant Depression is a relatively common occurrence in clinical practice, with 50–60% of the patients not achieving sufficient response following antidepressants for Treatment-resistant Depression.
Treatment-resistant Depression is usually linked to higher rates of comorbidity, particularly with other psychiatric disorders, chronic pain, and fibromyalgia. On the other hand, the impact of both physical and psychiatric illness c...
