CAR T-cell therapy is a type of immunotherapy that uses your body's white blood cells to fight your lymphoma. It uses a particular kind of white blood cell known as T lymphocytes or T cells. An essential part of CART therapies is lymphodepleting conditioning, which is administered to the patient before infusion of the CART product. Currently, there are only three FDA-approved CAR T-cell therapies for the treatment of patients in DLBCL. YESCARTA (Axicabtagene ciloleucel), KYMRIAH (tisagenlecleucel), and BREYANZI (lisocabtagene maraleucel) are autologous CAR T-cell products targeting CD19, which have been approved by the US FDA for the treatment of patients with DLBCL.
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