Enhertu with Opdivo exhibited clinical efficacy with an ORR of 36.7% in HER2+ urothelial cancer in Phase Ib study
On the second day of ASCO-GU 2022, the rapid abstract session highlighted the results from the DS8201-A-U105 trial (NCT03523572; Active, not recruiting) of Enhertu (trastuzumab deruxtecan) with Opdivo (nivolumab) in patients with HER2 expressing urothelial carcinoma. The results which were presented at the ASCO-GU symposium were from cohort 3 of the U105 Phase Ib trial, and the objective response rate by independent central review (ICR) was 36.7%, with 13.3% patients experiencing complete response (CR) and 23.3% patients experiencing the partial respons...
